Cullin ring ligases (CRLs) constitute the largest group of RING finger ubiquitin ligases. Two recent studies in Molecular Cell describe glomulin as a CRL1 inhibitor that blocks interactions with its ubiquitin-conjugating enzyme (E2) (Duda et al., 2012; Tron et al., 2012). These findings and their significance are discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448943 | PMC |
| http://dx.doi.org/10.1016/j.molcel.2012.07.025 | DOI Listing |
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