One case of renal leiomyosarcoma in an adult man with fast growth is presented. Clinical and iconographic features of the cases are compared with other cases reported and their diagnostic and therapeutic orientation discussed.
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Front Med (Lausanne)
January 2025
College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Over the past decade, the elderly Filipino population has significantly increased, rising from 4.6 million seniors, which was approximately 6% of the total population in 2000, to 6.5 million, or around 6.
View Article and Find Full Text PDFCurr Res Toxicol
December 2024
University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL 23826, United States.
Opioids have been the primary method used to manage pain for hundreds of years, however the increasing prescription rate of these drugs in the modern world has led to a public health crisis of overdose related deaths. Naloxone is the current standard treatment for opioid overdose rescue, but it has not been fully investigated for potential off-target toxicity effects. The current methods for pharmaceutical development do not correlate well with pre-clinical animal studies compared to clinical results, creating a need for improved methods for therapeutic evaluation.
View Article and Find Full Text PDFSci Rep
January 2025
Departmant of Orthopedics and Traumatology, Liv Ulus Hospital, Istanbul, Turkey.
Locking plates have a rapidly growing process especially in the past decades and results are satisfactory especially in the osteoporotic bones compared to non-locking compression plates. There are many forms of failure in the fracture fixation of locking plates, and screw pull-out is one of the main failure reasons. In this study, we aim to investigate pull-out failure in locking plates using locking spongious screws.
View Article and Find Full Text PDFProc Biol Sci
January 2025
Ecosystems and Global Change Group, Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK.
Understanding how species adapt to environmental change is necessary to protect biodiversity and ecosystem services. Growing evidence suggests species can adapt rapidly to novel selection pressures like predation from invasive species, but the repeatability and predictability of selection remain poorly understood in wild populations. We tested how a keystone aquatic herbivore, , evolved in response to predation pressure by the introduced zooplanktivore .
View Article and Find Full Text PDFPLoS Pathog
January 2025
School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
Porphyromonas gingivalis (Pg) is a keystone pathogen in periodontitis, a highly prevalent disease manifested by chronic inflammation of the periodontium, alveolar bone resorption and tooth loss. During periodontitis pathobionts such as Pg can enter the bloodstream and growing evidence correlates periodontitis with increased risk of cardiovascular and neurodegenerative diseases. However, the mechanism by which immune cells respond to Pg challenge in vivo remains elusive.
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