Results of the complex diagnosis and surgical treatment of 180 patients with perforation of gastroduodenal ulcers were analyzed. It was shown that in pathogenesis of perforations of chronic gastroduodenal ulcers the leading place belonged to oxidizing stress. A pathogenetically grounded method of treatment of perforations of chronic gastroduodenal ulcers is an excision of the perforated ulcers in combination with vagotomy, but the method of treatment of perforations of "silent" ulcers is videolaparoscopic suture with endoscopic transgastgric chemical vagotomy.
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