Morphological features of atypical and typical subtypes of pulmonary and thymic carcinoid tumors have been studied by pathohistological, immunohistochemical and electron-microscopic methods. There are the main principles of differential diagnostics in the article.
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Cureus
December 2024
Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, IND.
During bidirectional cavo-pulmonary anastomosis (bidirectional Glenn; BDG), the thymic tissue is often excised to facilitate the exposure of the superior vena cava and its junction with the innominate vein. Subsequently, it is discarded. Since the last two decades, the lead author (ST) has pursued anchoring the excised thymus in its position by suturing it to the opposite unexcised thymic lobe.
View Article and Find Full Text PDFFront Immunol
December 2024
Tavotek Biotherapeutics, Inc., Lower Gwynedd Township, PA, United States.
Introduction: Thymic stromal lymphopoietin (TSLP) is a master regulator of allergic inflammation against pathogens at barrier surfaces of the lung, skin, and gut. However, aberrant TSLP activity is implicated in various allergic, chronic inflammation and autoimmune diseases and cancers. Biologics drugs neutralizing excess TSLP activity represented by tezepelumab have been approved for severe asthma and are being evaluated for the treatments of other TSLP-mediated diseases.
View Article and Find Full Text PDFJ Exp Clin Cancer Res
December 2024
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200443, China.
Background: Thymic epithelial tumors (TETs) are infrequent malignancies that arise from the anterior mediastinum. Therapeutic options for TETs, especially thymic carcinoma (TC), remain relatively constrained. This study aims to investigate the oncogenic hub gene and its underlying mechanisms in TETs, as well as to identify potential therapeutic targets.
View Article and Find Full Text PDFKyobu Geka
October 2024
Department of Thoracic Surgery, Okazaki City Hospital, Okazaki, Japan.
A 70-year-old man presented with the growth of an anterior mediastinal nodule on a follow-up computed tomography (CT) scan after undergoing lung cancer surgery. Positron emission tomography (PET)-CT performed at the time of lung cancer surgery did not recognize any accumulation, but PET-CT performed this time confirmed the accumulation of standardized uptake value( SUV) max 5.57.
View Article and Find Full Text PDFJ Infect Dis
December 2024
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Myasthenia gravis (MG) is a rare autoimmune disorder characterised by muscle weakness resulting from autoantibody-mediated disruption of the neuromuscular junction. Notably, it is also frequently associated with thymic pathology. This study explores the relationship between MG and DNA viruses in the thymus, employing targeted NGS and qPCR to analyse thymic tissue samples from both MG patients and healthy controls.
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