The analysis is given of the technique, tolerance, clinical efficacy, safety, results of transurethral resection in physiological salt solution (TRPSS) performed in 788 patients from August, 2005 to November, 2010 for different diseases of the lower urinary tract and prostatic gland. TRPSS made it possible to operate patients whom transurethral resection was contraindicated, for example, those with a pacemaker, to reduce a complications rate, for instance, the obturator nerve reflex. Irrigation with isotonic salt solution prevents dilution hyponatriemia and TUR-syndrome thus increasing safe time of the resection for maximal removal of the tissue.

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