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Adagrasib in KRYSTAL-12 has Not Broken the KRAS G12C Enigma Code of the Unspoken 6-Month PFS Barrier in NSCLC.
Lung Cancer (Auckl)
December 2024
University of California Irvine School of Medicine, Department of Medicine, Orange, CA, 92868, USA.
Mutations in KRAS G12C are among the more common oncogenic driver mutations in non-small cell lung cancer (NSCLC). In December 2022, the US Food and Drug Administration (FDA) granted accelerated approval to adagrasib, a small molecule covalent inhibitor of KRAS G12C, for the treatment of patients with locally advanced or metastatic KRAS G12C mutant NSCLC who received at least one prior systemic therapy based on promising results from phase 1 and 2 trials wherein adagrasib demonstrated a median PFS of 6.5 months.
View Article and Find Full Text PDF"Busting the hidden curriculum" a realist and innovative perspective to foster professional behaviors.
Front Med (Lausanne)
December 2024
Centre for Professionalism in Medicine and Health Sciences, Faculty of Medicine and Health Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Contemporary health professions education has long delineated the desired attributes of medical professionalism in the form of standard curricula and their role in forming professional behaviors (PBs) among aspiring doctors. However, existing research has shown the contradictory and powerful role of hidden curriculum (HC) in negatively influencing medical students' PBs through unspoken or implicit academic, cultural, or social standards and practices. These contrasting messages of formal curricula and HC lead to discordance and incongruence in future healthcare professionals developing professional identity formation.
View Article and Find Full Text PDFBuilding a holistic health approach in supported housing for people with intellectual disabilities in Denmark.
Health Promot Int
December 2024
Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, Indgang A, 8200 Aarhus N, Denmark.
People with intellectual disabilities (IDs) face health issues and barriers to physical activity. Health promotion programmes targeting this group are often short-term. Few programmes have been designed for people with IDs who live in supported housing staffed by social care workers (SCWs).
View Article and Find Full Text PDFWhat must a medical student learn?
Postgrad Med J
November 2024
Internal Medicine Department, Medical School, Pontifical Catholic University of Paraná, R. Imac. Conceição, 1155 - Prado Velho, 80215-901, Curitiba, PR, Brazil.
Article Synopsis
- Studying medicine is an active and demanding process that requires dedication, curiosity, and continuous learning through various means like observation and reading.
- The essence of being a student is rooted in the eagerness to acquire knowledge, not just in scientific terms but also in understanding the human aspects of medicine.
- Developing skills like empathy, active listening, and trust-building is crucial for medical students to effectively connect with patients and provide both care and comfort.
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