Evidence-based medicine (EBM) aims to apply the best available evidences gained from scientific method to clinical decision making. From the computer science point of view, the current bottleneck of applying EBM by a decision maker (either a patient or a physician) is the time-consuming manual retrieval, appraisal, and interpretation of scientific evidences from large volume of and rapidly increasing medical research reports. Patients do not have the expertise to do it. For physicians, study has shown that they usually have insufficient time to conduct the task. CliniQA tries to shift the burden of time and expertise from the decision maker to the computer system. Given a single clinical foreground question, the CliniQA will return a highly reliable answer based on existing medical research reports. Besides this, the CliniQA will also return the analyzed information from the research report to help users appraise the medical evidences more efficiently.
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Biotechnol Bioeng
January 2025
Boehringer Ingelheim Pharma GmbH & Co.KG, Biopharmaceuticals Germany, Biberach an der Riß, Germany.
Process models are increasingly used to support upstream process development in the biopharmaceutical industry for process optimization, scale-up and to reduce experimental effort. Parametric unstructured models based on biological mechanisms are highly promising, since they do not require large amounts of data. The critical part in the application is the certainty of the parameter estimates, since uncertainty of the parameter estimates propagates to model predictions and can increase the risk associated with those predictions.
View Article and Find Full Text PDFUrologia
January 2025
Department of Urology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, Lucknow, Uttar Pradesh, India.
Introduction: Pseudotumors are benign lesions which may mimic like a malignant tumor on conventional imaging. They are formed in kidneys which are scarred and deformed by chronic pyelonephritis, glomerulonephritis, trauma or infarction. There is a diagnostic dilemma in most of the cases as to differentiate RCC and pseudotumors.
View Article and Find Full Text PDFNat Commun
January 2025
Laboratory of Molecular Translational Medicine, Center for Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Pubertal timing is highly variable and is associated with long-term health outcomes. Phenotypes associated with pubertal timing include age at menarche, age at voice break, age at first facial hair and growth spurt, and pubertal timing seems to have a shared genetic architecture between the sexes. However, puberty phenotypes have primarily been assessed separately, failing to account for shared genetics, which limits the reliability of the purported health implications.
View Article and Find Full Text PDFPhysiol Rep
January 2025
Faculty of Health Science and Medicine, Bond University, Robina, Queensland, Australia.
Police officers are exposed to high levels of stress. Serving on Special Weapons and Tactics (SWAT) teams is a highly demanding duty that may further increase levels of stress in police personnel. This stress may accumulate, thereby increasing allostatic load.
View Article and Find Full Text PDFSmall
January 2025
School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215009, China.
Eutectogels are recently emerged as promising alternatives to hydrogels owing to their good environmental stability derived from deep eutectic solvents (DES). However, construction of competent eutectogels with both high conductivity and mechanical toughness is still difficult to achieve yet highly demanded. In this work, new LMNP-PEDOT-CMC-AA (LPCA) eutectogels are prepared using acrylic acid (AA) and carboxymethylcellulose sodium (CMC) as polymeric networks, liquid metal nanoparticle-poly(3,4-ethylenedioxythiophene) (LMNP-PEDOT) are added as multifunctional soft fillers.
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