AI Article Synopsis
- Two new compounds called manadosterols A and B were discovered in a marine sponge from Indonesia.
- These compounds consist of two sulfonated sterol cores linked by side chains and demonstrate the ability to inhibit a specific protein interaction (Ubc13-Uev1A).
- Manadosterols A and B are notably more effective at inhibiting this interaction compared to the previous known natural inhibitor, leucettamol A.
Article Abstract
Two new dimeric sterols, manadosterols A (1) and B (2), were isolated from the marine sponge Lissodendryx fibrosa collected in Indonesia. The two compounds are comprised of two sulfonated sterol cores connected through the respective side chains. Manadosterols A (1) and B (2) inhibited the Ubc13-Uev1A interaction with IC(50) values of 0.09 and 0.13 μM, respectively. They are the second and third natural compounds showing inhibitory activities against the Ubc13-Uev1A interaction and are more potent than leucettamol A (IC(50), 106 μM), the first such inhibitor, isolated from another marine sponge.
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Article Synopsis
- Two new compounds called manadosterols A and B were discovered in a marine sponge from Indonesia.
- These compounds consist of two sulfonated sterol cores linked by side chains and demonstrate the ability to inhibit a specific protein interaction (Ubc13-Uev1A).
- Manadosterols A and B are notably more effective at inhibiting this interaction compared to the previous known natural inhibitor, leucettamol A.
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