Hypoglycemia is a rare life threatening adverse drug reaction associated with various fluoroquinolones like ciprofloxacin, gatifloxacin and levofloxacin. Moxifloxacin was considered safe in this regard. Only one case has been reported for moxifloxacin-induced hypoglycemia in a renal failure patient. Here, we are reporting the second case of hypoglycemia due to moxifloxacin without any major co-morbid condition.
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http://dx.doi.org/10.2174/157488612802715744 | DOI Listing |
J Diabetes Res
October 2016
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China ; Beijing Key Laboratory of Diabetes Research and Care, Beijing 100730, China.
The purpose of this study was to investigate the effect of moxifloxacin on HERG channel protein and glucose metabolism. HERG expression was investigated using immunohistochemistry. The whole-cell patch clamp method was used to examine the effect of moxifloxacin on HERG channel currents.
View Article and Find Full Text PDFEur J Pharm Sci
February 2014
Institute of Pharmacology and Toxicology, University of Braunschweig, D-38106 Braunschweig, Germany. Electronic address:
Hyper- and hypoglycaemias are known side effects of fluoroquinolone antibiotics, resulting in a number of fatalities. Fluoroquinolone-induced hypoglycaemias are due to stimulated insulin release by the inhibition of the KATP channel activity of the beta cell. Recently, it was found that fluoroquinolones were much less effective on metabolically intact beta cells than on open cell preparations.
View Article and Find Full Text PDFCurr Drug Saf
April 2012
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Gujarat, India.
Hypoglycemia is a rare life threatening adverse drug reaction associated with various fluoroquinolones like ciprofloxacin, gatifloxacin and levofloxacin. Moxifloxacin was considered safe in this regard. Only one case has been reported for moxifloxacin-induced hypoglycemia in a renal failure patient.
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