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http://dx.doi.org/10.1503/cmaj.112-2056DOI Listing

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Background: The idea of making science more accessible to nonscientists has prompted health researchers to involve patients and the public more actively in their research. This sometimes involves writing a plain language summary (PLS), a short summary intended to make research findings accessible to nonspecialists. However, whether PLSs satisfy the basic requirements of accessible language is unclear.

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Objectives: To predict and characterize the three-dimensional (3D) structure of protein arginine methyltransferase 2 (PRMT2) using homology modeling, besides, the identification of potent inhibitors for enhanced comprehension of the biological function of this protein arginine methyltransferase (PRMT) family protein in carcinogenesis.

Materials And Methods: An method was employed to predict and characterize the three-dimensional structure. The bulk of PRMTs in the PDB shares just a structurally conserved catalytic core domain.

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Historiography is a vital perspective of our scientific literature that charts the evolution of scientific publishing, from its early origins to the present status. The key transformations including the shift from a limited self-published legacy to specialized and professional peer-reviewed journals, the impact of technological advancements, and the emergence of new profitable business models are learning points for the future course and couture. Science is pursued and persevered by real humans in social and cultural contexts and not in isolation of laboratories or clinics.

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A year in review - evaluating the launch of IJTLD OPEN.

IJTLD Open

January 2025

International Union Against Tuberculosis and Lung Disease, Paris, France.

One year on from the launch of our new open access (OA) journal, IJTLD OPEN, we review its impact. Similar to our flagship journal, the IJTLD, articles published in IJTLD OPEN span a range of topics related to lung health and the majority focus on TB in low- to middle-income countries (LMICs). Interestingly, there has been no lag period in readers accessing the content, with downloads for IJTLD OPEN soon matching and exceeding those for the IJTLD.

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Introduction: Dementia is one of the most relevant widespread diseases, with a prevalence of currently 55 million people with dementia worldwide. However, about 60-75% of people with dementia have not yet received a formal diagnosis. Asymptomatic screening of cognitive impairments using neuropsychiatric tests has been proven to efficiently enhance diagnosis rates.

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