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4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
Adv Sci (Weinh)
January 2025
Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, P. R. China.
Myocardial ischemia-reperfusion (IR) injury is a critical complication following revascularization therapy for ischemic heart disease. Itaconate, a macrophage-derived metabolite, has been implicated in inflammation and metabolic regulation. This study investigates the protective role of itaconate derivatives against IR injury.
View Article and Find Full Text PDFMaternal milk cell components are uptaken by infant liver macrophages via extracellular vesicle mediated transport.
FASEB J
January 2025
Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Milk is a multifaceted biofluid that is essential for infant nutrition and development, yet its cellular and bioactive components, particularly maternal milk cells, remain understudied. Early research on milk cells indicated that they cross the infant's intestinal barrier and accumulate within systemic organs. However, due to the absence of modern analytical techniques, these studies were limited in scope and mechanistic analysis.
View Article and Find Full Text PDFCurcumin encapsulated in PAMAM dendrimers for the therapeutic treatment of ischemic stroke in rats.
Front Cell Dev Biol
January 2025
College of Medicine, Central Michigan University, Mount Pleasant, MI, United States.
Introduction: Ischemic stroke is a devastating neurovascular condition that occurs when cerebral tissue fails to receive an adequate supply of oxygen. Despite being a leading cause of death and disability worldwide, therapeutic interventions are currently limited. Polyamidoamine (PAMAM) dendrimers are nanomolecules commonly used in biomedical applications due to their ability to encapsulate small-molecules and improve their pharmacokinetic properties.
View Article and Find Full Text PDFVariation in compressive mechanical properties between subacute and chronic venous thrombosis in a novel unilateral iliac thrombosis model.
Vasc Med
January 2025
Department of Surgery, Section of Vascular Surgery, Conrad Jobst Vascular Laboratories, University of Michigan Health System, Ann Arbor, MI, USA.
Interventional therapies to relieve chronic deep vein thrombosis (DVT) fail through inability to penetrate, cross, and remove the occlusion. Development of suitable tools requires fundamental understanding of chronic DVT mechanical properties and a reliable model for testing. Female farm swine underwent a novel, endovenous generation of long-segment unilateral iliac vein thrombosis.
View Article and Find Full Text PDFEfficacy of shared decision making in tobacco cessation among health facilities of Haryana, India - A double blinded, parallel group Randomized Controlled trial Protocol.
Public Health Pract (Oxf)
June 2025
Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Background: Shared decision-making (SDM) incorporates evidence, patient values, and preferences into medical decision-making. SDM and decision aids might promote health professional engagement and patient knowledge of tobacco cessation therapy, improving usage and results. The SDM facilitates talks that lead to better-informed judgements that align with patients' priorities, unlike individual decision-making.
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