AI Article Synopsis
- The study examined how effective imipenem/cilastatin sodium (IPM) and other beta-lactams are against 353 different bacterial strains.
- IPM was very effective against several Gram-positive bacteria, including Staphylococcus and Enterococcus species.
- While IPM performed comparably or less effectively against certain Enterobacteriaceae, it was highly effective against Pseudomonas aeruginosa and Acinetobacter but not against Xanthomonas maltophilia.
Article Abstract
In vitro antibacterial activities of imipenem/cilastatin sodium (imipenem) and other beta-lactams against clinically isolated 353 bacterial strains were investigated. The results obtained in this study are summarized as follows: 1. Imipenem (IPM) showed potent antibacterial activities against Gram-positive cocci such as Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus agalactiae. 2. IPM had inferior or equivalent antibacterial activities to beta-lactams against clinically isolated Enterobacteriaceae, that is, Escherichia coli, Citrobacter freundii, Klebsiella pneumoniae, Serratia marcescens, Enterobacter cloacae, Enterobacter aerogenes and Proteus spp. 3. IPM showed potent antibacterial activities against clinically isolated Pseudomonas aeruginosa, Acinetobacter anitratus but not against Xanthomonas maltophilia.
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