AI Article Synopsis
- Bacteria use quorum sensing (QS) for cell communication, affecting gene expression based on their population.
- Autoinducer-2 (AI-2), a key QS signaling molecule found in many bacteria, is derived from DPD, but there’s still a lot to learn about how different species communicate.
- Researchers have created new DPD analogues called C4-alkoxy-HPDs, with some showing greater potency as QS activators than DPD in Vibrio harveyi, enhancing our understanding of the AI-2 QS system.
Article Abstract
Bacteria have developed cell-to-cell communication mechanisms, termed quorum sensing (QS), that regulate bacterial gene expression in a cell population-dependent manner. Autoinducer-2 (AI-2), a class of QS signaling molecules derived from (4S)-4,5-dihydroxy-2,3-pentanedione (DPD), has been identified in both Gram-negative and Gram-positive bacteria. Despite considerable interest in the AI-2 QS system, the biomolecular communication used by distinct bacterial species still remains shrouded. Herein, we report the synthesis and evaluation of a new class of DPD analogues, C4-alkoxy-5-hydroxy-2,3-pentanediones, termed C4-alkoxy-HPDs. Remarkably, two of the analogues were more potent QS agonists than the natural ligand, DPD, in Vibrio harveyi. The findings presented extend insights into ligand-receptor recognition/signaling in the AI-2 mediated QS system.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438919 | PMC |
| http://dx.doi.org/10.1021/ja305532y | DOI Listing |
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