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Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions.
Nat Commun
January 2025
School of Pharmacy, Nanjing University of Chinese Medicine, Xianlindadao No. 138, Nanjing, Jiangsu, China.
Protein lactylation is an emerging field. To advance the exploration of its biological functions, here we develop a comprehensive workflow that integrates proteomics to identify lactylated sites, genetic code expansion (GCE) for the expression of site-specifically lactylated proteins in living cells, and an integrated functional analysis (IFA) platform to evaluate their biological effects. Using a combined wet-and-dry-lab proteomics strategy, we identify a conserved lactylation at ALDOA-K147, which we hypothesize plays a significant biological role.
View Article and Find Full Text PDFEffects of L9 on Oral Microbiota and Cariogenic Factors in -Infected Mice.
Foods
December 2024
School of Food and Health, Beijing Technology and Business University, No. 11 Fucheng Road, Beijing 100024, China.
In the pathogenesis of dental caries, () plays a central role. can produce extracellular polysaccharides, which can help the bacteria form biofilms on the tooth surface, create a stable living environment, and hinder the removal of bacteria by natural defense substances in the oral cavity such as saliva. Meanwhile, the oral microbiota and dietary habits exert long-term influences on its development.
View Article and Find Full Text PDFReadiness to Embrace Artificial Intelligence Among Medical Students in Saudi Arabia: A National Survey.
Healthcare (Basel)
December 2024
College of Medicine, King Faisal University, Hofuf 31982, Saudi Arabia.
Background/objectives: Artificial intelligence (AI) is rapidly reshaping healthcare, offering transformative potential for diagnostics, treatment, and patient management. Despite its growing significance, there is limited integration of AI education in medical curricula, raising concerns about the readiness of future healthcare professionals to utilize AI technologies. This study aims to evaluate the readiness of medical students in Saudi Arabia to embrace AI and to assess the current state of AI education, AI Application use, and future perspectives for medical students.
View Article and Find Full Text PDFAssessing the prevalence of anticholinergic and sedative medications to avoid in older adults from the French Health Data System.
J Am Geriatr Soc
January 2025
Department of Pharmacy, Charpennes Hospital, Hospices Civils de Lyon, Villeurbanne, France.
Background: In older people, medications with anticholinergic or sedative properties are associated with falls, frailty, and functional and cognitive impairment. These medications are often described as a subset of potentially inappropriate medications (PIMs). We examined the prevalence of anticholinergic or sedative medications to avoid in older people in France in 2023.
View Article and Find Full Text PDFEffects of Large Language Model-Based Offerings on the Well-Being of Students: Qualitative Study.
JMIR Form Res
December 2024
Imperial College Business School, Imperial College London, London, United Kingdom.
Background: In recent years, the adoption of large language model (LLM) applications, such as ChatGPT, has seen a significant surge, particularly among students. These artificial intelligence-driven tools offer unprecedented access to information and conversational assistance, which is reshaping the way students engage with academic content and manage the learning process. Despite the growing prevalence of LLMs and reliance on these technologies, there remains a notable gap in qualitative in-depth research examining the emotional and psychological effects of LLMs on users' mental well-being.
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