We performed a comparative morphometric and immunohistochemical studies of the placentas collected in preterm labor after 27-33-week gestation. Predominating branched angiogenesis processes and more pronounced vascularization of the placental villi were found in the group of newborns with hemorrhagic complications. These changes were paralleled by high expression of VEGF in all villous structures.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-012-1723-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Expression of the IGF‑1Ea isoform in human placentas from third trimester normal and idiopathic intrauterine growth restriction singleton pregnancies: Correlations with clinical and histopathological parameters.
Mol Med Rep
March 2025
Department of Pathology, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Intrauterine growth restriction (IUGR) is the second most common obstetric complication after preterm labor. Appropriate trophoblast differentiation and placental structure, growth and function are key for the maintenance of pregnancy and normal fetal growth, development and survival. Extravillous trophoblast cell proliferation, migration and invasion are regulated by molecules produced by the fetomaternal interface, including autocrine factors produced by the trophoblast, such as insulin‑like growth factor (IGF)‑1.
View Article and Find Full Text PDFEmbryoscopy and targeted embryo biopsy for the management of early abortion.
J Assist Reprod Genet
January 2025
Centro de Asistencia a La Reproducción Humana de Canarias, La Laguna, Santa Cruz de Tenerife, Spain.
Purpose: To evaluate the safety, accuracy, and effectiveness of embryoscopy for the management of early abortion and to test the hypothesis that targeted embryo and chorionic villi sampling avoids maternal cell contamination (MCC) for genetic testing of products of conception (POC).
Methods: This ambispective study included 74 consecutive patients presenting with early abortion. Gestations between 5 and 9 weeks, obtained either spontaneously or through assisted reproductive technologies were included.
The Interplay of Molecular Factors and Morphology in Human Placental Development and Implantation.
Biomedicines
December 2024
Department II of Microscopic Morphology, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
The placenta is a vital organ that supports fetal development by mediating nutrient and gas exchange, regulating immune tolerance, and maintaining hormonal balance. Its formation and function are tightly linked to the processes of embryo implantation and the establishment of a robust placental-uterine interface. Recent advances in molecular biology and histopathology have shed light on the key regulatory factors governing these processes, including trophoblast invasion, spiral artery remodeling, and the development of chorionic villi.
View Article and Find Full Text PDFLipid imbalance and inflammatory oxylipin cascade at the maternal-fetal interface in recurrent spontaneous abortion.
Heliyon
December 2024
Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- RSA is linked to metabolic imbalances at the maternal-fetal interface, especially concerning essential fatty acids and oxylipins, which may contribute to the risk of spontaneous abortion.
- Research involved analyzing samples from women experiencing spontaneous abortion and those with normal pregnancies, measuring fatty acid levels and enzyme expressions using advanced techniques like GC-MS and LC-MS.
- Findings showed that women with recurrent spontaneous abortion had higher omega-6 fatty acid levels in their plasma and chorionic villi but lower levels in the decidua, suggesting a possible dysregulation of fatty acid transport affecting pregnancy outcomes.
Activated PRDM1-CREBBP contributes to preeclampsia by regulating apoptosis and invasion of the human trophoblast cells.
iScience
December 2024
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, P.R. China.
Preeclampsia (PE) is a multifactorial disorder of pregnancy, characterized by new-onset gestational hypertension. High-throughput mRNA sequencing (RNA-seq) was performed to analyze the gene expression patterns in placentas from patients with early-onset PE (EOPE). PR domain zinc-finger protein 1 (PRDM1) expression increased in the chorionic villi and placental basal plate from patients with PE and nitro--arginine methyl ester (L-NAME)-treated rats.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!