Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds.

Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally inflicted wounds in rats.

Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University.

Results: Morin showed significant wound contraction on day 7 as compared to control with mean closure of 47.44±6.07% in excision wound model. Granulation tissue breaking strength was significantly increased (p<0.05) in the morin treated group with 180.2±7.94 g when compared to control at 151.2±6.99 g. There was a significant increase in hydroxyproline content with the morin treated group when compared to control with 3.41±0.33 μg/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing.

Conclusions: Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.