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Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial.
Mil Med Res
October 2022
Department of Psychiatry, the Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, 510370, China.
Background: Although clozapine is an effective option for treatment-resistant schizophrenia (TRS), there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine. The main purpose of this randomized, double-blind, placebo-controlled trial was to explore the amisulpride augmentation efficacy on the psychopathological symptoms and cognitive function of clozapine-resistant treatment-refractory schizophrenia (CTRS) patients.
Methods: A total of 80 patients were recruited and randomly assigned to receive initial clozapine plus amisulpride (amisulpride group) or clozapine plus placebo (placebo group).
Systematic review and network meta-analysis: efficacy of drugs for functional dyspepsia.
Aliment Pharmacol Ther
January 2021
School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Background: Functional dyspepsia (FD) is a relapsing and remitting condition affecting between 5% and 10% of people. Efficacious therapies are available, but their relative efficacy is unknown.
Aim: To perform a systematic review with network meta-analysis to resolve this uncertainty.
UV-Fenton degradation of diclofenac, sulpiride, sulfamethoxazole and sulfisomidine: Degradation mechanisms, transformation products, toxicity evolution and effect of real water matrix.
Chemosphere
November 2020
School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, 510632, China; Department of Civil & Environmental Engineering, National University of Singapore, 1 Engineering Drive 2, Singapore, 117576, Singapore. Electronic address:
Four common refractory pharmaceuticals, diclofenac (DF), sulpiride (SP), sulfamethoxazole (SMX) and sulfisomidine (SIM) were detected in the Disc Tubular Reverse Osmosis (DTRO) concentrates with higher concentrations ranging from 0.85 to 11.57 μg/L from the local landfill.
View Article and Find Full Text PDFBenefit of small dose antidepressants for functional dyspepsia: Experience from a tertiary center in eastern China.
Medicine (Baltimore)
October 2019
Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou.
Background: Traditional treatment of functional dyspepsia (FD) is unsatisfactory in a subgroup of patients with FD, and the potential role of antidepressant medications also has not been definitely clarified. To provide more evidence for future optimal practice recommendations, we reviewed a 1-year clinical database of antidepressant agents applied in outpatients with FD.
Methods: Clinical presentations, treatment course, and outcomes were determined by chart review of patients referring to the functional gastrointestinal disorders specialist clinic.
[Rumination].
Korean J Gastroenterol
December 2017
Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Rumination syndrome is one of the functional gastroduodenal disorders. Effortless and repetitive regurgitation of recently ingested food from the stomach to the oral cavity followed by rechewing and reswallowing or spitting are the characteristic clinical features. This disorder is believed to be uncommon, but many patients with this disorder are overlooked by their physicians.
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