Structured decision making and value-of-information analyses can be used to identify robust management strategies even when uncertainty about the response of the system to management is high. We used these methods in a case study of management of the non-native invasive species gray sallow willow (Salix cinerea) in alpine Australia. Establishment of this species is facilitated by wildfire. Managers are charged with developing a management strategy despite extensive uncertainty regarding the frequency of fires, the willow's demography, and the effectiveness of management actions. We worked with managers in Victoria to conduct a formal decision analysis. We used a dynamic model to identify the best management strategy for a range of budgets. We evaluated the robustness of the strategies to uncertainty with value-of-information analyses. Results of the value-of-information analysis indicated that reducing uncertainty would not change which management strategy was identified as the best unless budgets increased substantially. This outcome suggests there would be little value in implementing adaptive management for the problem we analyzed. The value-of-information analyses also highlighted that the main driver of gray sallow willow invasion (i.e., fire frequency) is not necessarily the same factor that is most important for decision making (i.e., willow seed dispersal distance). Value of-information analyses enables managers to better target monitoring and research efforts toward factors critical to making the decision and to assess the need for adaptive management.
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http://dx.doi.org/10.1111/j.1523-1739.2012.01907.x | DOI Listing |
J Environ Manage
January 2025
Bielefeld University, Faculty of Business Administration and Economics, Universitätsstraße 25, 33615 Bielefeld, Germany; Helmholtz-Institute for Functional Marine Biodiversity at the University of Oldenburg (HIFMB), Im Technologiepark 5, 26129 Oldenburg, Germany; Fraunhofer Center for International Management and Knowledge Economy IMW, Leipziger Straße 70/71, 06108 Halle (Saale), Germany.
Environmental decision-making is inherently subject to uncertainty. However, decisions are often urgent, and whether to take direct action or invest in collecting additional data beforehand is pervasive. To make this trade-off explicit, the value of information (VoI) theory offers a powerful decision analytic tool to quantify the expected benefit of resolving uncertainty in a decision context.
View Article and Find Full Text PDFValue Health
November 2024
Health Economics Unit, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, England, UK; Global Health and Global Surgery Unit, National Institute for Health and Care Research (NIHR), University of Birmingham, Birmingham, England, UK.
Objectives: There is uncertainty around whether, and under what circumstances, there is value in embedding economic considerations into multiarm, multistage (MAMS) adaptive, and adaptive platform trial designs. This systematic review was conducted to assess the analytical methods and factors that are considered when incorporating health economic analyses when designing and modifying MAMS adaptive and adaptive platform trials.
Methods: The review searched for health economic analyses, including planned analyses, of interventions assessed through MAMS adaptive, and adaptive platform trials.
Lancet Glob Health
December 2024
National University Hospital, Singapore; Infectious Diseases Translational Research Program, National University of Singapore, Singapore; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Background: The REGARD-VAP trial showed that individualised shortened antibiotic therapy was non-inferior to usual care for mortality and pneumonia recurrence in patients with ventilator-associated pneumonia (VAP). We aimed to assess the cost-effectiveness of an individualised shortened antibiotic therapy approach in this planned economic analysis.
Methods: REGARD-VAP was a phase 4, multicentre, open-label, randomised trial to assess a short-course antibiotic treatment strategy for treatment of VAP.
Pharmacoeconomics
November 2024
Centre for Health Economics Research and Evaluation, University of Technology Sydney, Sydney, NSW, Australia.
Background And Objective: This systematic literature review addresses model-based cost-effectiveness studies for therapy response monitoring with positron emission tomography (PET) generally combined with low-dose computed tomography (CT) for various cancer types. Given the known heterogeneity in therapy response events, studies should consider patient-level modelling rather than cohort-based modelling because of its flexibility in handling these events and the time to events. This review aims to identify the modelling methods used and includes a systematic assessment of the assumptions made in the current literature.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
October 2024
School of Civil Engineering, College of Engineering, University of Tehran, Tehran, Iran.
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