AI Article Synopsis
- The spleen contains various types of myeloid and dendritic cells, which are crucial for activating and managing the adaptive immune response.
- Dendritic cells (DC) specialize in capturing and presenting antigens to naïve T cells, but there are different subsets of DC, each with unique characteristics and functions.
- The review focuses on identifying and characterizing these splenic subsets to enhance our understanding of their specific roles in immunity.
Article Abstract
The spleen contains multiple subsets of myeloid and dendritic cells (DC). DC are important antigen presenting cells (APC) which induce and control the adaptive immune response. They are cells specialized for antigen capture, processing and presentation to naïve T cells. However, DC are a heterogeneous population and each subset differs subtly in phenotype, function and location. Similarly, myeloid cell subsets can be distinguished which can also play an important role in the regulation of immunity. This review aims to characterize splenic subsets of DC and myeloid cells to better understand their individual roles in the immune response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118229 | PMC |
| http://dx.doi.org/10.1111/j.1582-4934.2012.01608.x | DOI Listing |
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