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On the Analysis of Protein Genetic Architecture: Response to "Protein sequence landscapes are not so simple".
bioRxiv
December 2024
Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA.
We recently reanalyzed 20 combinatorial mutagenesis datasets using a novel reference-free analysis (RFA) method and showed that high-order epistasis contributes negligibly to protein sequence-function relationships in every case. Dupic, Phillips, and Desai (DPD) commented on a preprint of our work. In our published paper, we addressed all the major issues they raised, but we respond directly to them here.
View Article and Find Full Text PDFEditorial Commentary: Thoughtful Application of Artificial Intelligence Technique Improves Diagnostic Accuracy and Supportive Clinical Decision-Making.
Arthroscopy
December 2024
Commons Clinic (J.J.W., P.N.R.); Warren Alpert Brown School of Medicine (J.J.W., A.J.Y., R.Y.H.).
Medical research within areas of deep learning, particularly in computer vision for medical imaging, has shown promise over the past decade with an increasing volume of technical papers published in orthopaedics related to imaging artificial intelligence (AI). However, as more tools and models are developed and deployed, it is easy for clinicians to get overwhelmed with the different types of models, leaving "artificial intelligence" as an empty buzzword where true value can be unclear. As with surgery, the techniques of deep learning require thoughtful application and cannot follow a one-size-fits-all approach as different problems require differential levels of technical complexity with model application.
View Article and Find Full Text PDFPediatric obesity and treatment controversies: Is the use of medications too good to be true?
Am J Health Syst Pharm
December 2024
Kentucky Children's Hospital at UK HealthCare, Lexington, KY, USA.
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
View Article and Find Full Text PDFResponse to commentary by Mattos et al. (2024).
J Consult Clin Psychol
November 2024
RTI International.
Replies to comments made by Mattos et al. (see record 2025-49982-003) on the original article (see record 2024-19816-001). Mattos et al.
View Article and Find Full Text PDFCountering Coloniality in Global Health Comment on "The Rhetoric of Decolonizing Global Health Fails to Address the Reality of Settler Colonialism: Gaza as a Case in Point".
Int J Health Policy Manag
December 2024
Graduate School of Social Work, University of Denver, Denver, CO, USA.
This commentary joins the chorus of rightful critiques of global health as it continues to further colonial agendas under the guise of supposed well-meaning efforts. Engebretsen and Baker rightfully call out the uptake of decolonial rhetoric in the field of global health, pointing out notable failures to actually challenge undergirding colonial structures and move beyond theory into meaningful action, using clear examples from the ongoing crisis in Gaza and global health's ongoing response (or lack thereof). In this work I bring together essential foundations of decolonial scholarship in order to further the work Engebretsen and Baker have defined as crucial reckoning points for the field of global health.
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