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The Quinine Odyssey: A Barometer of the State of Organic Synthesis Over Centuries.
Chemistry
December 2024
School of Natural Sciences-Chemistry, University of Tasmania, Hobart, Tasmania, 7001, Australia.
The year 2024 marks the 80 anniversary of the landmark formal synthesis of (±)-quinine completed by Woodward and Doering. This article examines the evolution of approaches to access this storied Cinchona alkaloid natural product which represent a microcosm the progress that has been made in organic synthesis over the past ~170 years. Seminal contributions led by Pasteur, Rabe, Woodward, Uskoković, Stork, Jacobsen, Hayashi, Maulide and others are discussed.
View Article and Find Full Text PDFHPMA copolymer-antibody constructs in neoplastic treatment: an overview of therapeutics, targeted diagnostics, and drug-free systems.
J Control Release
September 2020
Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic. Electronic address:
In the past decades, nanosized drug delivery systems based on N-(2-hydroxypropyl)methacrylamide copolymers (pHPMA) have gained increasing attention in nanomedicine field due to their hydrophilicity, versatility, biocompatibility, non-toxicity, and non-immunogenicity. Indeed, pHPMA nanosystems with various controlled drug release capabilities inside targeted tissues or cells have been intensively studied. This paper summarizes recent advances in the design and application of pHPMA conjugates with specific antibodies or their fragments, focusing predominantly on the systems for the cancer therapy, particularly, the mechanisms of action of therapeutic antibodies, the approaches of their modification and subsequent attachment of pHPMA and their conjugates with diverse active moieties.
View Article and Find Full Text PDFOverview of the 80(th) Annual Scientific Meeting of the Japanese Circulation Society - The Past, Present and Future of Cardiovascular Medicine in Japan - - The 5(th) Anniversary of the Great East Japan Earthquake.
Circ J
July 2016
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
The 80(th)Annual Scientific Meeting of the Japanese Circulation Society was held in Sendai, Japan, on March 18-20, 2016, which coincided with the 5(th)anniversary of the Great East Japan Earthquake that hit the Tohoku area on March 11, 2011. Thus, the main themes for this meeting were "The Past, Present and Future of Cardiovascular Medicine in Japan" and "The 5(th)Anniversary of the Great East Japan Earthquake". Despite the provincial location, approximately 15,000 people attended during the 3-day meeting, and there were in-depth discussions in each of the various sessions on these themes.
View Article and Find Full Text PDFIn June 2016, Professor Daniil Fishelevich Gluzman, well-known Ukrainian oncohematologist, celebrates his 80(th) anniversary.
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