AI Article Synopsis
- Partial splenic artery embolization is a successful treatment for hypersplenism in patients with liver cirrhosis, achieving 100% technical success without major complications.
- Post-embolization, patients showed a significant increase in white blood and platelet counts, with levels remaining higher than before the procedure over four years, despite a gradual decline after peaking at two weeks.
- CT scans indicated changes in splenic volume, and the treatment was deemed safe with no major adverse effects on red blood cell count or liver function.
Article Abstract
Background: Partial splenic artery embolization is an effective treatment for hypersplenism but often lacks long-term benefits.
Purpose: To evaluate the long-term effects of coil embolization of the splenic artery in patients with liver cirrhosis and hypersplenism.
Material And Methods: Forty-nine patients with liver cirrhosis and hypersplenism underwent coil embolization of the main splenic artery. The coils were deployed in the mid- or distal segment of the splenic artery to allow collateral blood flow to the spleen. The following data were collected from 2 weeks to 4 years after the embolization: technical success, length of hospital stay, white blood cell count, platelet count, splenic volume, and complication.
Results: The technical success rate of splenic artery coil embolization was 100%. The post embolization syndrome rate was 75% (36/49) with no incidence of major complications. The mean length of hospital stay was 9 days. After embolization, the patient's white blood and platelet counts increased significantly, peaked at 2 weeks, and gradually decreased during the 4-year follow-up period, but remained at significantly higher levels than pre-embolization levels. Follow-up CT scans demonstrated a gradual increase in the volume of the enhanced portions of the spleens with a decrease in the volume of unenhanced portion. No significant changes occurred in the red blood cell count and liver function after the embolization.
Conclusion: Embolization of the mid-and distal main splenic artery with coils is a safe and effective treatment of hypersplenism in cirrhosis with long-term hematologic benefits.
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| http://dx.doi.org/10.1258/ar.2012.110639 | DOI Listing |
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