Purpose: The purpose of this study is to determine the association between the BIK/NBK gene expression and estrogen receptor alpha expression.
Materials And Methods: We determined the association of BIK/NBK gene expression by real time quantitative reverse transcription polymerase chain reaction and estrogen receptor alpha expression by immunohistochemistry in samples of breast cancer tissue.
Results: We found a statistically significant correlation of BIK/NBK gene expression with the estrogen receptor alpha expression (ρ = 0.751, p = 0.004). For verify differences of BIK/NBK gene expression among ERα+ and ERα- breast cancer tissues, Mann-Whitney U test was performed, obtaining significant differences.
Conclusions: BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients according to the estrogen receptor alpha expression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12094-012-0845-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Correlation of the protein expression of GRP78 and BIK/NBK with prognostic markers in patients with breast cancer and neoadjuvant chemotherapy.
J Obstet Gynaecol
April 2020
Medical Research Unit in Human Genetics, Unidad Médica de Alta Especialidad (UMAE) Hospital de Pediatría, Dr. Silvestre Frenk Freund, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
The objective of this study was to determine the frequency of expression of GRP78 and BIK/NBK proteins, as well as to evaluate their correlation with prognostic factors for clinical use in patients with locally advanced breast cancer (LABC) or preoperative chemotherapy (PC). An observational, analytical and retrospective study that evaluated the expression of BIK/NBK and GRP78 by means of immunohistochemistry in paraffin-embedded tumour tissue samples obtained before the start of PC was executed. GRP78 was positive in 93.
View Article and Find Full Text PDFBIK is involved in BRAF/MEK inhibitor induced apoptosis in melanoma cell lines.
Cancer Lett
September 2017
Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, Wuerzburg, Germany. Electronic address:
In patients with BRAF-mutated melanoma specific inhibitors of BRAF and MEK1/2 frequently induce initial tumor reduction, frequently followed by relapse. As demonstrated previously, BRAF-inhibition induces apoptosis only in a fraction of treated cells, while the remaining arrest and survive providing a source or a niche for relapse. To identify factors contributing to the differential initial response towards BRAF/MEK inhibition, we established M14 melanoma cell line-derived single cell clones responding to treatment with BRAF inhibitor vemurafenib and MEK inhibitor trametinib predominantly with either cell cycle arrest (CCA-cells) or apoptosis (A-cells).
View Article and Find Full Text PDFRepression of the proapoptotic cellular BIK/NBK gene by Epstein-Barr virus antagonizes transforming growth factor β1-induced B-cell apoptosis.
J Virol
May 2014
School of Biotechnology and National Centre for Sensor Research, Dublin City University, Dublin, Ireland.
Unlabelled: The Epstein-Barr virus (EBV) establishes a lifelong latent infection in humans. EBV infection of primary B cells causes cell activation and proliferation, a process driven by the viral latency III gene expression program, which includes EBV nuclear proteins (EBNAs), latent membrane proteins, and untranslated RNAs, including microRNAs. Some latently infected cells enter the long-lived memory B-cell compartment and express only EBNA1 transiently (Lat I) or no EBV protein at all (Lat 0).
View Article and Find Full Text PDFBIK (NBK) is a mediator of the sensitivity of Fanconi anaemia group C lymphoblastoid cell lines to interstrand DNA cross-linking agents.
Biochem J
November 2012
Servicio de Hematología, Instituto de Formación e Investigación Marqués de Valdecilla-IFIMAV, Santander, Spain.
FA (Fanconi anaemia) is a rare hereditary disorder characterized by congenital malformations, progressive bone marrow failure and an extraordinary predisposition to develop cancer. At present, 15 genes have been related to this condition and mutations of them have also been found in different types of cancer. Bone marrow failure threatens the life of FA patients during the first decade of their life, but the mechanisms underlying this process are not completely understood.
View Article and Find Full Text PDFBIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients.
Clin Transl Oncol
August 2012
Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN S-XXI), Instituto Mexicano del Seguro Social (IMSS), Mexico D.F., Mexico.
Purpose: The purpose of this study is to determine the association between the BIK/NBK gene expression and estrogen receptor alpha expression.
Materials And Methods: We determined the association of BIK/NBK gene expression by real time quantitative reverse transcription polymerase chain reaction and estrogen receptor alpha expression by immunohistochemistry in samples of breast cancer tissue.
Results: We found a statistically significant correlation of BIK/NBK gene expression with the estrogen receptor alpha expression (ρ = 0.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!