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IFCC standardised HbA(1c): should the world be as one? | LitMetric

IFCC standardised HbA(1c): should the world be as one?

Clin Chem Lab Med

Department of Clinical Biochemistry, Norfolk and Norwich University Hospital, Norwich Medical School, University of East Anglia, Norwich, UK.

Published: February 2012

The central importance of HbA(1c) in monitoring glycaemic control was highlighted by the Diabetes Control and Complications Trial (DCCT) which showed that improved glycaemic control, as monitored by HbA(1c), delayed the onset of diabetic complications. Following this publication the issue of international standardisation of glycated haemoglobin (GHb) measurements became an important objective. The lack of international standardisation resulted in several countries developing National Standardisation Programmes. The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Working Group on HbA(1c) Standardisation has established a reference measurement procedure (HPLC-MS or HPLC-CE) for HbA(1c) embracing the concept of metrological traceability. The reference method is anchored to a global network of 15 approved reference laboratories; this confers sustainability and a low level of uncertainty. Essential elements of a comprehensive reference measurement system additionally include the definition of the measurand and the unit of measurement. HbA(1c) is defined as haemoglobin (Hb) molecules having a stable adduct of glucose to the N-terminal valine of the β chain [Hb β chain (Blood) - N-(1-deoxyfructos-1-yl) Hb β chain] and that mmol/mol be used as the unit of measurement. These developments will result in improvements in inter-method and inter-laboratory agreement. Additionally, global acceptance of standardisation based on metrologically sound principles will enable clinical goals and diagnostic guidelines to be developed that can be adopted by all countries.

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Source
http://dx.doi.org/10.1515/cclm-2011-0853DOI Listing

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