[The clinico-immunological characteristics of viral hepatitis A in adolescent girls].

A study of viral hepatitis A in adolescent girls revealed the effect of menstrual cycle phases on the character of the course of the disease. It was established that the critical point of unfavourable course of the disease is coincidence of the days of height of the disease with the follicular peak of estrogen secretion (8-10 day of the cycle). During this period the patients showed a significant quantitative and functional insufficiency of the T-lymphocytic system of immunity and the functional liver tests were highly pathologic. These patients should be considered as high risk patients as to unfavourable course of the disease and development of acute liver failure.