The non-contact and lubrication free support of magnetic bearings make them ideal to support rotating machines. One area of application of magnetic bearings is in the design of the mechanical heart pumps. The LifeFlow heart pump developed by the University of Virginia is one such heart pump which uses active and passive magnetic bearings to support the impeller. The design and controls of such bearings can be quite challenging. One of the major difficulties that one may encounter in designing the controller is to get accurate values of the control parameters such as bias flux, radial and axial stiffness values, forces, etc. In order to obtain these parameters accurately, a three dimensional finite element analysis of the magnetic bearings is crucial. This paper covers the analysis of the magnetic bearing system used in the LifeFlow Heart pump. The main purpose of the analysis was to provide accurate values of air gap flux, forces, radial and axial stiffness in order to design a robust and optimized controller for the bearings. As a result of the analysis, these parameters have been determined and the motor is being redesigned with a smaller footprint to achieve higher efficiency.
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Int J Pharm
January 2025
The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157 Xiwu Road, Xi'an, Shaanxi 710004, China. Electronic address:
Both photothermal therapy (PTT) and chemodynamic therapy (CDT) are designed to focus their antitumor effect on only the tumor site, thereby minimizing unwanted severe damage to healthy tissue outside the tumor. However, each monotherapy is limited in achieving complete tumor eradication, resulting in tumor recurrence. The combination of multiple therapies may help to overcome the limitations of single therapy, improve the chances of complete tumor eradication, and reduce the risk of recurrence.
View Article and Find Full Text PDFSci Rep
January 2025
School of Earth Sciences, China University of Geosciences, Wuhan, 430074, Hubei, China.
Soil magnetic records in Quaternary red earth (QRE) deposits contain a valuable record of paleoclimate information, providing insights into controls on Earth's climate system in the past and potentially helping to predict its response to perturbations in the future. Here, analysis of the environmental magnetism and mineralogy of the Xuancheng QRE (Anhui Province, South China) shows that magnetic variation was strongly linked to production of authigenic ferrimagnetic minerals such as maghemite. Fine-grained maghemite formed during the weathering-related transformation of iron-bearing illite to vermiculite, generating aggregates of vermiculite or mixed-layer illite-vermiculite.
View Article and Find Full Text PDFEur J Radiol
January 2025
Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:
Purpose: To quantitatively verify whether degeneration in the quality of the medial femoral cartilage is correlated with muscle volume loss and intramuscular adipose tissue (IntraMAT) infiltration in quadriceps using magnetic resonance imaging (MRI).
Methods: Of the 66 older adult participants ≥60 years old (74.5 ± 6.
Mater Today Bio
February 2025
Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
The large recruitment of tumor-associated macrophages and low exposure of tumor-associated antigens in tumor microenvironment have severely suppress the efficacy of anti-tumor immunotherapy. Herein, biosynthesized magnetosome (Mag) from bacteria was loaded with photothermal/photodynamic agent/near infrared (NIR) fluorescence dye (IR780) and further modified with lipid-PEG-c(RGDyK) through biomembrane, forming Mag for fluorescence imaging, magnetic resonance imaging, immunotherapy and photodynamic/photothermal therapy. After intravenous injection into B16F10 tumor-bearing mice, Mag could efficiently accumulate in tumor tissues based on near infrared (NIR) fluorescence and magnetic resonance dual-modality imaging, and repolarize tumor-associated macrophages (TAMs) from M2 phenotype to M1 phenotype, significantly improving the effect of tumor immunotherapy.
View Article and Find Full Text PDFJ Mater Chem B
January 2025
Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Breast Center, Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Development of novel Gd-based contrast agents for targeted magnetic resonance imaging (MRI) of liver cancer remains a great challenge. Herein we reported a novel Gd-based MRI contrast agent with improved relaxivity for specifically diagnosing liver cancer. This GSH-responsive macromolecular contrast agent (mCA), POLDGd, was prepared by RAFT polymerization, and its lactic acid moiety could precisely target the ASGP-R surface protein on liver cancer cells, whereas PODGd without the lactic acid moiety was prepared as a control.
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