Alterations in excitability of low-, medium- and high-threshold single mechanoreceptors (SMRs) of hairless hind paw skin elicited by transcranial electrical stimulation (TES) in analgesic regime were studied in anesthetized rats. Evoked impulsations of low- and medium-threshold SMRs were blocked by TES that lasted for about 1 and 5 min, respectively. TES for 18-20 min in duration abolished the reactions of high threshold SMRs activated only by nociceptive stimuli. Inhibitory effects of TES on all SMR types under study were eliminated by preliminary intraperitoneal or local intracutaneous (near SMRs location) injection of naloxone. Possible mechanisms of analgesic TES effects are discussed. An assumption is made that alterations of the SMR function are connected with an increase of the output of endogenous opioid peptides from the brain during TES.
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