AI Article Synopsis
- The study demonstrates how (R)-(+) and (S)-(-)-1-phenylethylamine can facilitate specific and selective chemical reactions, known as [3 + 2] carbocyclizations, that combine certain compounds to create valuable products.
- The reactions resulted in enantiomerically rich compounds called 2-hydroxy-3-nitrocyclopentanone derivatives, which have potential applications in various fields.
- Methods of analysis, including X-ray and circular dichroism spectroscopy, were used to determine the precise configurations of the resulting products.
Article Abstract
(R)-(+) and (S)-(-)-1-phenylethylamine have been shown to promote highly diastereoselective and complementary enantioselective formal [3 + 2]carbocyclization reactions between 2,3-butanedione and conjugated nitroalkenes with formation of enantiomerically rich 2-hydroxy-3-nitrocyclopentanone derivatives. The reactions were carried out both in solvent and under solvent-free conditions. The absolute configurations of the products were assigned by X-ray and circular dichroism spectra analyses.
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| http://dx.doi.org/10.1002/chir.22088 | DOI Listing |
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