AI Article Synopsis

  • A series of 3-nitrochromenes were created, showing effective inhibition of thioredoxin reductase (TrxR) and reduced proliferation of A549 cancer cells.
  • The structure-activity relationship analysis highlights that the 3-nitrochromene structure is essential for its inhibitory effects.
  • Introducing bromo groups at the 6- and 8- positions of 3-nitrochromene enhances its inhibitory activity significantly.

Article Abstract

A series of 3-nitrochromenes were designed and synthesized. These compounds showed good inhibitory activity against thioredoxin reductase (TrxR) and the proliferation of A549 cancer cells. The structure-activity relationship analysis indicates that the 3-nitrochromene scaffold is the crucial pharmacophore for achieving good inhibitory activity. The bromo-substitutions at the 6- and 8-position of 3-nitrochromene significantly increase the inhibitory activity.

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http://dx.doi.org/10.1002/ardp.201200121DOI Listing

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