AI Article Synopsis
- The lipase B from Candida antarctica (Novozym 435®) was effective in separating enantiomers of several aliphatic secondary alcohols, showing high selectivity.
- The enzyme produced enantiopure alcohols and acetates with over 99% enantiomeric excess (ee) and yielded good results.
- Kinetic resolution was accomplished using straightforward conditions, employing vinyl acetate as the acylating agent and hexane as the solvent.
Article Abstract
The lipase B from Candida antarctica (Novozym 435®, CALB) efficiently catalyzed the kinetic resolution of some aliphatic secondary alcohols: (±)-4-methylpentan-2-ol, (±)-5-methylhexan-2-ol, (±)-octan-2-ol, (±)-heptan-3-ol and (±)-oct-1-en-3-ol. The lipase showed excellent enantioselectivities in the transesterifications of racemic aliphatic secondary alcohols producing the enantiopure alcohols (>99% ee) and acetates (>99% ee) with good yields. Kinetic resolution of rac-alcohols was successfully achieved with CALB lipase using simple conditions, vinyl acetate as acylating agent, and hexane as non-polar solvent.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268719 | PMC |
| http://dx.doi.org/10.3390/molecules17088955 | DOI Listing |
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