AI Article Synopsis
- Non-small cell lung carcinoma (NSCLC) is influenced by environmental and genetic factors, and this study focused on the role of killer immunoglobulin-like receptor (KIR) genes and their ligands in NSCLC susceptibility and treatment response.
- KIR genes were not linked to NSCLC, but specific gene combinations, particularly C1C1 homozygotes, were more frequent in NSCLC patients than healthy controls.
- Patients with KIR2DL2 and KIR2DS2 genes who were also homozygous for the C1 ligand showed a significantly better treatment response and longer median survival (23 months) compared to those with different genotypes (10 months).
Article Abstract
Non-small cell lung carcinoma (NSCLC) is a multifactorial disease influenced by both environmental and genetic factors. Here, we examined whether the repertoire of genes encoding killer immunoglobulin-like receptors (KIR) and genes for their ligands, C1/C2 and Bw4, may affect a susceptibility to NSCLC and response to treatment. We typed 269 NSCLC patients and 690 healthy control individuals for KIR genes and for their ligands. KIR genes were not associated with NSCLC. C1C2 genotype was less frequent whereas both C1C1 and C2C2 homozygotes were more frequent in patients than in controls (χ(2)=7.73; df=2; p=0.021). Patients positive for KIR2DL2 and KIR2DS2 gene and homozygous for the C1 ligand were 6 times more likely to respond to treatment than those with other genotypes (p=0.034). In accordance with this, patients with the KIR2DL2+/KIR2DS2+, C1C1 genotype survived longer than others (p=0.0094). Median survival was 23months for KIR2DL2/2DS2/C1C1-positive patients, but only 10 months for those with other genotypes.
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| http://dx.doi.org/10.1016/j.humimm.2012.07.323 | DOI Listing |
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