A recent study suggests that circadian clocks may have evolved at the time of the Great Oxidation Event 2.5 billion years ago in order to drive detoxification of reactive oxygen species.
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The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection to metabolism is particularly significant, as it plays a critical role in energy regulation and distribution within organisms. Over recent decades, metabolism has emerged as a relevant focus in studies of biological regulation, especially following its recognition as a hallmark of cancer.
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Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
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Department of Zoology and Entomology, University of Pretoria, Pretoria, 0002, South Africa; Mammal Research Institute, University of Pretoria, Hatfield, 0083, South Africa. Electronic address:
The genus Otomys exhibits diverse activity patterns in the field, making them ideal subjects for studying circadian biology. The Southern African vlei rat (Otomys auratus) has previously been categorised as diurnal or crepuscular, but also displays some nocturnal activity. This study aimed to confirm the temporal niche of vlei rats in a laboratory setting and examine changes in activity when provided with a running wheel.
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