As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.
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| http://dx.doi.org/10.1016/j.ejmech.2012.07.001 | DOI Listing |
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