AI Article Synopsis
- * Various techniques like karyotyping and flow cytometry are used to assess chromosome structure and cell characteristics.
- * The review highlights the importance of conducting standard tests to identify chromosomal issues in adult stem cells before transplantation to improve treatment outcomes.
Article Abstract
The usefulness of adult stem cells in research and therapeutic applications highly relies on their genomic integrity and stability. Many laboratories including ours have addressed this concern using methods such as karyotyping, Qbanding, fluorescent in situ hybridization, array CGH, flow cytometry and Pap test to evaluate number and structure of chromosomes and cellular phenotype. This review attempts to summarize the findings reported so far for the studies on chromosomal aberrations in adult stem cells and warrant to perform certain basic tests before transplantation to avoid any adverse reactions, which will thus aid in better therapeutic output after cellular transplantation in the treatment of various diseases.
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| http://dx.doi.org/10.2174/157488812802481472 | DOI Listing |
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