Intravenous hypertonic saline to reduce intraocular pressure.

Acta Ophthalmol

Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, FinlandDepartment of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland.

Published: November 2013

Purpose: To quantitate the effect of intravenous hypertonic saline (IVHTS) injection on elevated intraocular pressure (IOP).

Methods:   Nineteen patients (median age, 65 years; range, 41-84 years) with glaucoma and an IOP 30 mmHg or higher were recruited. A bolus of IVHTS (sodium chloride concentration 23.4%) was injected in an antecubital vein over 10-20 seconds. The IOP and systolic and diastolic blood pressure (BP) were measured frequently for 2 hr. The dosage was 0.5 mmol/kg sodium in 11 patients (Group 1) and 1.0 mmol/kg in eight patients (Group 2).

Results:   In both groups, a median absolute IOP reduction of 7 mmHg was achieved in 5 min. The maximum median reduction was 7 mmHg (range, 4-16) and 9 mmHg (range, 3-14) at 5 and 16 min after IVHTS in Group 1 and 2, respectively, at which point the median IOP had reduced from 38 and 35 mmHg to 31 and 27 mmHg (p < 0.001), respectively. In both groups, the IOP remained 7 mmHg reduced 2 hr after IVHTS. Systolic BP increased a median of 14.5 mmHg at 3 min and was comparable with baseline after 6 min.

Conclusion: Intravenous hypertonic saline solution reduces IOP moderately within minutes for up to 2 hr.

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Source
http://dx.doi.org/10.1111/j.1755-3768.2012.02474.xDOI Listing

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