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This article contains analysis of retrospective and prospective studies of use of selective ultrashort Beta-blocker esmolol during intraoperative period in cardiac surgery patients in recent years. The drug is highly effective and controlled the means for prevention and treatment of tachycardia, arising as a result of the sympathoadrenal system activation during anaesthesia induction (laryngoscopy, trachea intubation) and intraoperative period (during heart and aorta manipulations). It should be considered that the use of esmolol has dose-dependent effect. For the treatment of tachycardia against the background of hypertension is recommended dose of 0.6-1.0 mg/kg, with normal blood pressure it is recommended to decrease the esmolol dose up to 0.3-0.6 mg/kg. It is possible to use esmolol-infusion in the dose of 50-200 g/kg/min prolonging adrenergic blockade during heart and aorta surgery.
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