Russian and foreign approaches to estimating the combined effect of substances are considered depending on the problems to be solved Data are given on the relationship of the type of combined effect to the mechanism of the toxic action of components and acting doses (concentrations). Various mathematical models for calculating the combined efect of mixtures are discussed There is evidence that it is necessary to study the combined effects of the mixtures of constant composition, which are used in water supply upon chronic exposure of the substances that are constituents of the mixtures. Based on their studies and the data available in the literature, the authors inferred that the nature of the combined effect of such mixtures should be investigated under the conditions suiting those of application, as well as when used at low concentrations.
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