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Exploiting nutrient transporters at the blood-brain barrier to improve brain distribution of small molecules. | LitMetric
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Exploiting nutrient transporters at the blood-brain barrier to improve brain distribution of small molecules.

Rajendar K Mittapalli Vamshi K Manda Chris E Adkins Werner J Geldenhuys Paul R Lockman

Ther Deliv

Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106-1712, USA.

Published: December 2010

The blood-brain barrier (BBB) is a major physiological barrier for drugs that target CNS receptors or enzymes. Several methods exist by which permeability to the CNS can be increased, one of which is using native nutrient transporters to carry these drugs through the endothelial cells of the BBB. In this review, we focus on work that characterizes the use of nutrient transporters of the BBB in delivering drugs to the CNS.

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http://dx.doi.org/10.4155/tde.10.76DOI Listing

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