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Metabolites in the Dance: Deciphering Gut-Microbiota-Mediated Metabolic Reprogramming of the Breast Tumor Microenvironment.
Cancers (Basel)
December 2024
Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg (UKGM), Philipps University Marburg, Baldinger Str., 35043 Marburg, Germany.
Breast cancer (BC), a major cause of death among women worldwide, has traditionally been linked to genetic and environmental factors. However, emerging research highlights the gut microbiome's significant role in shaping BC development, progression, and treatment outcomes. This review explores the intricate relationship between the gut microbiota and the breast tumor microenvironment, emphasizing how these microbes influence immune responses, inflammation, and metabolic pathways.
View Article and Find Full Text PDFReactive oxygen species: Orchestrating the delicate dance of platelet life and death.
Redox Biol
January 2025
School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, China; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China. Electronic address:
Article Synopsis
- Platelets play a critical role in blood clotting and the immune response, relying on a balanced relationship between their production and destruction influenced by reactive oxygen species (ROS).
- Moderate levels of ROS enhance platelet production and function, aiding in processes like collagen binding and thrombus formation, but high levels can lead to platelet apoptosis and increased risk of thrombosis.
- The review emphasizes the need for further research into specific ROS signaling pathways, which could lead to new therapies for platelet-related disorders by leveraging the beneficial aspects of ROS while managing their harmful effects.
Rave gone wrong: MDMA- induced medical emergency at electrical daisy carnival. A case report.
Toxicol Rep
December 2024
Kirk Kerkorian School of Medicine at UNLV, Department of Internal Medicine, 625 Shadow Lane, Las Vegas 89106, USA.
Article Synopsis
- A 35-year-old male suffered a life-threatening overdose at the festival, experiencing seizures and hyperthermia, leading to his emergency intubation and treatment for multiple organ failure.
- The case emphasizes the need for quick medical intervention to save lives after MDMA overdoses and highlights the importance of raising awareness about the risks associated with using this drug at music events.
Impact of Spiritual Support Interventions on the Quality of Life of Patients Who Receive Palliative Care: A Systematic Review.
Nurs Rep
August 2024
Department of Nursing, Pharmacology and Physiotherapy, Cordoba University, Avda Menendez Pidal s/n, 14071 Córdoba, Spain.
Background: Palliative care focuses on the prevention of worsening health, improving the quality of the patient's life, and the relief of suffering, and therefore has a considerable impact on both the patient suffering from a life-threatening or potentially life-threatening illness and on their family. Spirituality, as the dimension of human life involving the search for meaning, purpose, and transcendence, and connection with oneself, others, and the sacred, could be essential in supporting these patients. The aim of this study was to synthesise the scientific evidence describing the interventions and/or activities undertaken to meet the spiritual needs of the palliative patient.
View Article and Find Full Text PDFEcstasy-Induced Rhabdomyolysis Leading to Severe Acute Kidney Injury Requiring Temporary Hemodialysis: A High Risk for Recurrence With Repeated Exposure.
Cureus
July 2024
Internal Medicine, Richmond University Medical Center, Staten Island, USA.
Ecstasy (3,4-methylenedioxymethyl-amphetamine, MDMA) is an illicit drug that has found widespread use. It is mostly used by adolescents and young adults, particularly during intense and prolonged dance parties for its mood-enhancing properties. Despite these pleasurable effects, users may have potentially serious side effects including death.
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