Genomic and serological detection of bat coronavirus from bats in the Philippines.
Arch Virol
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Published: December 2012
AI Article Synopsis
- Researchers studied bat coronaviruses (BtCoVs) in the Philippines, collecting samples from 179 bats and detecting viral RNA in 29.6% of them.
- Phylogenetic analysis indicated that one BtCoV was a new type of alphacoronavirus, while others were part of the Betacoronavirus genus.
- Additionally, 66.5% of bat sera tested positive for antibodies against BtCoV, indicating that these viruses are commonly found among bats in the region.
Article Abstract
Bat coronavirus (BtCoV) is assumed to be a progenitor of severe acute respiratory syndrome (SARS)-related coronaviruses. To explore the distribution of BtCoVs in the Philippines, we collected 179 bats and detected viral RNA from intestinal or fecal samples by RT-PCR. The overall prevalence of BtCoVs among bats was 29.6 %. Phylogenetic analysis of the partial RNA-dependent RNA polymerase gene suggested that one of the detected BtCoVs was a novel alphacoronavirus, while the others belonged to the genus Betacoronavirus. Western blotting revealed that 66.5 % of bat sera had antibodies to BtCoV. These surveys suggested the endemic presence of BtCoVs in the Philippines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086765 | PMC |
| http://dx.doi.org/10.1007/s00705-012-1410-z | DOI Listing |
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