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An atlas of neuropathic pain-associated molecular pathological characteristics in the mouse spinal cord.
Commun Biol
January 2025
Department of Anesthesiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Peripheral nerve injury (PNI)-induced neuropathic pain (NP) is a severe disease with high prevalence in clinics. Gene reprogramming and tissue remodeling in the dorsal root ganglia (DRG) and spinal cord (SC) drive the development and maintenance of neuropathic pain (NP). However, our understanding of the NP-associated spatial molecular processing landscape of SC and the non-synaptic interactions between DRG neurons and SC cells remains limited.
View Article and Find Full Text PDFReduction in the olfactory ability in aging mutant mice without evidence of neurodegeneration.
Front Aging
October 2024
Department of Anatomy, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Age-related decline occurs in most brain structures and sensory systems. An illustrative case is olfaction. The olfactory bulb (OB) undergoes deterioration with age, resulting in reduced olfactory ability.
View Article and Find Full Text PDFAbnormal Regulation of Mitochondrial Sphingolipids during Aging and Alzheimer's Disease.
ASN Neuro
November 2024
Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Article Synopsis
- Mitochondrial dysfunction during Alzheimer's disease (AD) is linked to low energy production and increased reactive oxygen species, but the exact mechanisms, particularly related to sphingolipid metabolism, remain unclear.
- In experiments with 5xFAD mice, researchers found that synaptic mitochondria display reduced oxygen consumption and altered protein levels related to energy production as early as 3 months of age.
- The study identified abnormal sphingolipid levels in the mitochondria of 5xFAD mice, with increased long-chain ceramides and sphingosine, indicating that these lipid changes may contribute to mitochondrial dysfunction in early AD development.
The role of astrocytes from synaptic to non-synaptic plasticity.
Front Cell Neurosci
October 2024
Department of Neurosciences, Université de Montréal, Montréal, QC, Canada.
Information storage and transfer in the brain require a high computational power. Neuronal network display various local or global mechanisms to allow information storage and transfer in the brain. From synaptic to intrinsic plasticity, the rules of input-output function modulation have been well characterized in neurons.
View Article and Find Full Text PDFSynaptic mitochondria: A crucial factor in the aged hippocampus.
Ageing Res Rev
November 2024
Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago 8580702, Chile; Facultad de Medicina y Ciencia, Universidad San Sebastián, Lota 2465, Santiago 7510157, Chile. Electronic address:
Aging is a multifaceted biological process characterized by progressive molecular and cellular damage accumulation. The brain hippocampus undergoes functional deterioration with age, caused by cellular deficits, decreased synaptic communication, and neuronal death, ultimately leading to memory impairment. One of the factors contributing to this dysfunction is the loss of mitochondrial function.
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