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Fine-grained imaging of mouse brain cells suggests "pearling" of axons that may help with signaling.
View Article and Find Full Text PDFTowards a molecular picture of the archaeal cell surface.
Nat Commun
November 2024
Living Systems Institute, University of Exeter, Exeter, UK.
Archaea produce various protein filaments with specialised functions. While some archaea produce only one type of filament, the archaeal model species Sulfolobus acidocaldarius generates four. These include rotary swimming propellers analogous to bacterial flagella (archaella), pili for twitching motility (Aap), adhesive fibres (threads), and filaments facilitating homologous recombination upon UV stress (UV pili).
View Article and Find Full Text PDFLoss of Myofibrils in Cardiomyocytes as a Morphological Indicator of Reduced Compensatory Capabilities of Hypertrophied Myocardium.
Bull Exp Biol Med
November 2024
A. N. Bakulev Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.
The functioning of the ventricular myocardium in hypertrophic cardiomyopathy (HCM) under high hemodynamic load leads to depletion of its resources and is associated with the risk of developing a dilated stage. In patients with HCM, the cardiomyocytes of the interventricular septum are hypertrophied, the proportion of cardiomyocytes in which myofibrils constitute less than 50% of the sarcoplasm volume increases with increasing the cardiomyocyte length and correlates with echocardiographic signs of left ventricular obstruction. These cardiomyocytes are characterized by ultrastructural signs of synthetic activity.
View Article and Find Full Text PDFSystematic screens for fertility genes essential for malaria parasite transmission reveal conserved aspects of sex in a divergent eukaryote.
Cell Syst
November 2024
The Laboratory for Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden; Department of Molecular Biology, Umeå University, Umeå, Sweden. Electronic address:
Article Synopsis
- Sexual reproduction in malaria parasites is crucial for their transmission to mosquitoes and helps researchers explore the evolution of sexual reproduction across different eukaryotes.
- A genetic study of Plasmodium berghei has identified 348 genes involved in sex and transmission, revealing new targets for potential interventions to block transmission.
- The study highlights the importance of two proteins, SUN1 and ALLC1, in male fertility by connecting cellular structures necessary for sperm development, suggesting a long-standing role for these proteins across species, including in mouse testes.
Antifreeze protein type I in the vitrification solution improves the cryopreservation of immature cat oocytes.
Theriogenology
November 2024
Faculdade de Veterinária, Universidade Federal Fluminense, Av. Vital Brazil Filho, 64, CEP 24230-340, Niterói, RJ, Brazil. Electronic address:
Oocyte cryopreservation is not yet considered a reliable technique since it can reduce the quality and survival of oocytes in several species. This study determined the effect of different concentrations of antifreeze protein I (AFP I) on the vitrification solution of immature cat oocytes. For this, oocytes were randomly distributed in three groups and vitrified with 0 μg/mL (G0, 0 μM); 0.
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