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http://dx.doi.org/10.1002/emmm.201201509 | DOI Listing |
Cells
November 2024
Faculty of Physical Education, Gdansk University of Physical Education and Sport, Górskiego 1 Street, 80-336 Gdansk, Poland.
Physical activity increases the risk of non-contact injuries, mainly affecting muscles, tendons, and ligaments. Genetic factors are recognized as contributing to susceptibility to different types of soft tissue injuries, making this broad condition a complicated multifactorial entity. Understanding genetic predisposition seems to offer the potential for personalized injury prevention and improved recovery strategies.
View Article and Find Full Text PDFOncogene
March 2017
Division of Molecular Therapy, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.
The transcription factor nuclear factor-κB (NF-κB) has important roles for tumorigenesis, but how it regulates cancer stem cells (CSCs) remains largely unclear. We identified insulin-like growth factor 2 (IGF2) is a key target of NF-κB activated by HER2/HER3 signaling to form tumor spheres in breast cancer cells. The IGF2 receptor, IGF1 R, was expressed at high levels in CSC-enriched populations in primary breast cancer cells.
View Article and Find Full Text PDFEMBO Mol Med
August 2012
Laboratory for Molecular Cancer Biology, Center for the Biology of Disease, VIB-KULeuven, Leuven, Belgium.
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