Post-dengue fever severe aplastic anemia: a rare association.

Hematol Oncol Stem Cell Ther

Pediatric Hematology Oncology and Bone Marrow Transplantation Unit, Department of Pediatrics, Institute of Child Health, Sir Ganga Ram Hospital, Delhi, India.

Published: February 2013

Dengue fever has rarely been reported as an etiology for aplastic anemia. An 8-year-old girl was admitted with fever, myalgia and petechiae. Dengue virus IgM antibodies were positive. She recovered completely, but her thrombocytopenia persisted. Six weeks later she became pancytopenic. A bone marrow aspirate and biopsy showed severe aplastic anemia. She was treated with antithymocytic immunoglobulin, methylprednisolone and cyclosporine. She became transfusion independent 6 months later. Dengue-virus induced aplastic anemia is a rare entity, but it must be identified early for better outcome. Immunosuppressive therapy can induce remission.

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http://dx.doi.org/10.5144/1658-3876.2012.122DOI Listing

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