AI Article Synopsis
- Extra-facial melasma is a common skin condition with unique clinical features and potential causes, impacting various populations.
- A study involving 90 participants compared extra-facial melasma patients with healthy volunteers, assessing clinical characteristics and conducting biopsies to analyze skin differences.
- Findings indicated that the melasma group was predominantly older women, often post-menopausal, with a notable family history, while histopathological analysis showed increased melanin density and signs of skin damage, although the number of melanocytes did not differ significantly between the groups.
Article Abstract
Background: Extra-facial melasma is a prevalent dermatosis in some populations with special characteristics in relation to its clinical aspects and probable etiopathogenic factors. Few studies have attempted to address this alteration of pigmentation, which has become a challenge in clinical Dermatology.
Objective: To assess the clinical histopathological and immunohistochemical characteristics of extra-facial melasma, comparing affected, and unaffected sites.
Methods: Case-control study with 45 patients in each group (melasma and disease-free volunteers), assessing their clinical characteristics. In 36 patients, biopsies were performed on the lesion and the normal perilesional skin. Specimens were stained with HE and Fontana-Masson, and melanocytes analysed by immunohistochemistry. Objective measurements were accomplished by a specifically designed image analysis software.
Results: The melasma group had a mean age ± SD of 56.67 ± 8 years, the majority of them were women (86.7%) and 82.1% of the female cases had reached menopause. There were no significant differences between groups in terms of presence of comorbidities, use of medications or hormone therapies. For extra-facial melasma patients, family history of this dermatose and of previous facial melasma was significantly higher than in the control group (P < 0.05). The HE staining showed increased rectification and basal hyperpigmentation, solar elastosis, and collagen degeneration in the pigmented area (P < 0.05). There was a significant increase in melanin density in melasma biopsies, but the immunohistochemical tests did not detect a difference between the groups in terms of number of melanocytes.
Conclusion: Extra-facial melasma appears to be related to menopause, family history, and personal history of facial melasma, in the studied population. Histopathology revealed a pattern similar to what has been described for facial melasma, with signs of solar degeneration, and a similar number of melanocytes, when comparing patients, and controls, suggesting that the hyperpigmentation is most likely the result of abnormal melanin production or distribution.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1468-3083.2012.04655.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Melasma: A Clinical and Epidemiological Single-Group Observational Study in the Greek Population.
Dermatol Ther (Heidelb)
November 2024
1st Department of Dermatology-Venereology, Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: Melasma is a common acquired disorder of melanogenesis that predominately affects women and presents as hyperpigmented skin lesions mainly located on the face. The study aims to investigate the epidemiologic characteristics and hormonal profiles in melasma patients.
Methods: One hundred fifty patients were enrolled in this study in a tertiary care hospital.
Is reflectance confocal microscopy useful in the differential diagnosis of extra facial lentigo maligna? A retrospective multicentric case-control study.
J Eur Acad Dermatol Venereol
December 2023
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Background: Extra facial lentigo maligna (EF-LM) arises outside the head and neck area. EF-LM presents the classic histological features of lentigo maligna. The dermoscopic aspects of EF-LM have been poorly studied.
View Article and Find Full Text PDFComparison of acquired bilateral nevus of Ota-like macules in men and women.
Indian J Dermatol Venereol Leprol
April 2015
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Background: The clinical and histopathological characteristics of acquired bilateral nevus of Ota-like macules in men are poorly documented due to its rarity.
Aims: To compare the clinical and histopathological characteristics of acquired bilateral nevus of Ota-like macules in men with the condition in women.
Methods: We studied 11 men and 62 women, all with a clinical diagnosis of acquired bilateral nevus of Ota-like macules.
Epidemiology of melasma in Brazilian patients: a multicenter study.
Int J Dermatol
April 2014
Cosmetic Dermatology at the Department of Dermatology, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS; Brazilian Center for Studies in Dermatology, Porto Alegre, RS.
Background: Melasma is an acquired, irregularly patterned, light to dark-brown hypermelanosis, with symmetric distribution mostly over the face. The aim of this study was to evaluate clinical characteristics and factors related to melasma in Brazilian patients.
Methods: This was a cross-sectional, multicenter study performed in Brazil.
Extra-facial melasma: clinical, histopathological, and immunohistochemical case-control study.
J Eur Acad Dermatol Venereol
September 2013
Department of Dermatology, Hospital de Clínicas de Porto Alegre, School of Medicine, Federal University of Rio Grande do Sul, Brazil.
Article Synopsis
- Extra-facial melasma is a common skin condition with unique clinical features and potential causes, impacting various populations.
- A study involving 90 participants compared extra-facial melasma patients with healthy volunteers, assessing clinical characteristics and conducting biopsies to analyze skin differences.
- Findings indicated that the melasma group was predominantly older women, often post-menopausal, with a notable family history, while histopathological analysis showed increased melanin density and signs of skin damage, although the number of melanocytes did not differ significantly between the groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!