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A foundation model of transcription across human cell types.
Nature
January 2025
Program of Mathematical Genomics, Department of Systems Biology, Columbia University, New York, NY, USA.
Transcriptional regulation, which involves a complex interplay between regulatory sequences and proteins, directs all biological processes. Computational models of transcription lack generalizability to accurately extrapolate to unseen cell types and conditions. Here we introduce GET (general expression transformer), an interpretable foundation model designed to uncover regulatory grammars across 213 human fetal and adult cell types.
View Article and Find Full Text PDFEmborrhoid technique in hemorrhoidal disease: Retrospective analysis of data from a single center.
Ulus Travma Acil Cerrahi Derg
January 2025
Department of General Surgery, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul-Türkiye.
Background: This study evaluates the safety and effectiveness of coil embolization of the superior rectal artery for both emergency and elective treatment of rectal bleeding caused by Goligher grade 4 hemorrhoids, where surgery is contraindicated.
Methods: Between 2019 and 2024, 18 patients (11 males, 7 females) with a mean age of 65±10.3 years were included in the study.
Bidimensionally partitioned online sequential broad learning system for large-scale data stream modeling.
Sci Rep
December 2024
College of Information Engineering, Yancheng Teachers University, Yancheng, 224002, China.
Incremental broad learning system (IBLS) is an effective and efficient incremental learning method based on broad learning paradigm. Owing to its streamlined network architecture and flexible dynamic update scheme, IBLS can achieve rapid incremental reconstruction on the basis of the previous model without the entire retraining from scratch, which enables it adept at handling streaming data. However, two prominent deficiencies still persist in IBLS and constrain its further promotion in large-scale data stream scenarios.
View Article and Find Full Text PDFPredictive nomogram of ultrasound indicators for the termination outcome of caesarean scar pregnancy.
Sci Rep
December 2024
Department of Ultrasound, The First Hospital of Hunan University of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410021, Hunan, People's Republic of China.
To develop and validate a nomogram for predicting the risk of adverse events (intraoperative massive haemorrhage or retained products of conception) associated with the termination of Caesarean scar pregnancy (CSP). Data were retrospectively collected from patients diagnosed with CSP who underwent Dilation and Curettage (D&C) at two hospitals. This data was divided into internal and external cohorts for analysis.
View Article and Find Full Text PDFThe conversion of tropical rainforests to agriculture causes population declines and biodiversity loss across taxa. This impacts ants (Formicidae), a crucial tropical group for ecosystem functioning. While biodiversity loss among ants is well documented, the responses of individual ant taxa and their adjustments in trophic strategies to land-use change are little studied.
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