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High mortality in bobwhite quail chicks () (35%-85%) was reported from a grower flock in Iowa during July and August of 2022. Two diagnostic submissions of dead, 3-day-old quail chicks were received. Postmortem examination revealed multifocal, pinpoint, pale tan foci in the liver of all birds.
View Article and Find Full Text PDFElectroencephalographic (EEG) Stages in Patients With Cerebral Edema Following Cardiac Arrest.
J Child Neurol
November 2024
Division of Epilepsy and Neurophysiology, Children's National Hospital, Washington DC, USA.
Objective: To describe electroencephalographic (EEG) changes in pediatric patients with cerebral edema after cardiac arrest.
Methods: A retrospective study of patients admitted to the pediatric intensive care unit from July 2021 to January 2023. We included patients with cardiac arrest and changes in EEG background with clinical changes and/or neuroimaging consistent with cerebral edema.
Complement activation by IgM autoantibodies linked to immune-mediated neuropathies depends on C2.
Eur J Neurol
January 2025
argenx, Ghent, Belgium.
Background And Purpose: Complement factor C2 is a potential therapeutic target in immune-mediated neuropathies. However, literature suggests that classical complement pathway activation may proceed to C3 in the absence of C2, a so-called "C2 bypass." Here, we evaluated a C2 bypass mechanism during complement activation by pathogenic human IgM from patients with immune-mediated neuropathies.
View Article and Find Full Text PDFDescriptive Analysis of Common Fusion Mutations in Papillary Thyroid Carcinoma in Hungary.
Int J Mol Sci
October 2024
Department of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Thyroid cancer is the most common type of endocrine malignancy. Papillary thyroid carcinoma (PTC) is its predominant subtype, which is responsible for the vast majority of cases. It is true that PTC is a malignant tumor with a very good prognosis due to effective primary therapeutic approaches such as thyroidectomy and radioiodine (RAI) therapy.
View Article and Find Full Text PDFThe peculiar clinical presentation and diagnostic results of a case of widely metastatic cholangiocellular carcinoma in a Siberian Husky dog.
Top Companion Anim Med
December 2024
Department of Comparative Pathobiology, Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA 01536, USA. Electronic address:
Article Synopsis
- A six-year-old spayed female Siberian Husky presented with cervical pain, ataxia, respiratory changes, and significant weight loss, leading to a battery of diagnostic tests.
- Findings indicated serious health issues, including spinal myelopathy and signs suggestive of metastatic carcinoma, prompting humane euthanasia and further investigation through necropsy.
- The necropsy revealed multiple tumors consistent with cholangiocellular carcinoma, highlighting challenges in prior diagnostics and an unusual presentation with cervical pain likely linked to spinal metastasis.
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