Background And Objectives: Data of a previously published study have shown that chronic obstructive pulmonary disease (COPD) patients have increased serum levels of CRP and fibrinogen. The aim of this work is to investigate if there was any correlation between inflammation factors and severity of COPD.
Design And Settings: A case control study conducted on 43 COPD patients and 40 healthy controls.
Patients And Methods: COPD were selected according to GOLD criteria. Exclusion criteria were acute exacerbation of disease in the past 4 weeks, usage of oral corticosteroids and presence of any comorbidity which could raise level of inflammatory proteins. Control group were healthy individuals. Serum levels of CRP and fibrinogen were measured.
Results: The mean serum level of CRP in COPD patients was significantly higher than that of controls (p = 0.03). No significant difference was found in the mean serum level of fibrinogen between cases and controls. Also, there were no significant correlation between the serum level of CRP or fibrinogen and severity of the disease and arterial 02 saturation.
Conclusion: According to our study results, COPD, per se, can increase serum CRP level. Attenuation of systemic inflammation may offer new perspectives in the management of COPD and its comorbidities.
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http://dx.doi.org/10.5455/medarh.2012.66.159-160 | DOI Listing |
JAMA Dermatol
January 2025
Centre for Molecular Medicine and Biobanking, University of Malta, Malta.
Importance: Variation in nicastrin (NCSTN) is associated with a monogenic subtype of hidradenitis suppurativa. Dysregulation of humoral immunity has been suggested as a potential mechanistic link between NCSTN variation and hidradenitis suppurativa. There is a paucity of biomarkers that can predict disease-associated variation.
View Article and Find Full Text PDFJ Vis Exp
January 2025
Department of Cardiac Surgery, the First Affiliated Hospital of Xinjiang Medical University;
The objective of this study was to investigate the cardioprotective effects of Munziq on abnormal body fluid myocardial ischemia-reperfusion injury (MIRI) and its underlying mechanism.Normal rats and rats with abnormal body fluid (ABF) were pre-treated with Munziq for 21 days. Following this, MIRI models were established.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
January 2025
Institute of Radiation Medicine, Fudan University, Xietu Road 2094, Shanghai, 200032, China.
Objectives: Mesothelin (MSLN) is an antigen that is overexpressed in various cancers, and its interaction with tumor-associated cancer antigen 125 plays a multifaceted role in tumor metastasis. The serum MSLN expression level can be detected using enzyme-linked immunosorbent assay; however, non-invasive visualization of its expression at the tumor site is currently lacking. Therefore, the aim of this study was to develop a molecular probe for imaging MSLN expression through positron emission tomography (PET).
View Article and Find Full Text PDFLasers Med Sci
January 2025
Laboratory of Pathophysiology Experimental, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
Unlabelled: This study aimed to evaluate gold nanoparticles (GNPs) and photobiomodulation (PBM), associated with antibothropic serum (AS), to treat a muscle lesion induced by Bothrops jararaca venom.
Methods: 108 Swiss male mice were used, divided into nine groups (n = 12) with different combinations of treatments. Animals were inoculated with 250 µg of B.
Mol Neurobiol
January 2025
Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, 200433, China.
Weightlessness usually causes disruption of the gut microbiota and impairs cognitive function. There is a close connection between gut microbiota and neurological diseases. Low-intensity pulsed ultrasound (LIPUS) has a beneficial effect on reducing intestinal inflammation.
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