3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one (Mutagen X, MX) was synthesized in six steps from commercially-available and inexpensive starting materials (27% overall yield). This synthesis enables the preparation of MX analogs and does not require the use of chlorine gas, as do previously reported methods.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398704 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2012.04.044 | DOI Listing |
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