AI Article Synopsis
- The development of the vertebrate nervous system starts with cells from the midline dorsal-ectoderm during the early stages of embryo formation, leading to the formation of diverse neuronal and glial cells in the central nervous system (CNS).
- Research primarily focused on spinal cord development has revealed key signaling events and genetic networks responsible for establishing the dorsal-ventral (DV) patterning of the neural plate.
- The review emphasizes recent findings on three main signaling factors: Sonic hedgehog, Wnts, and Bone Morphogenetic Proteins, while also addressing gaps in knowledge related to dorsal signaling mechanisms.
Article Abstract
Development of the vertebrate nervous system begins with the acquisition of neural identity from the midline dorsal-ectodermal cells of the gastrulating embryos. The subsequent progressive specification of the neural plate along its anterior-posterior and dorsal-ventral (DV) axes allows the generation of the tremendous variety of neuronal and glial cells that compose the vertebrate central nervous system (CNS). Studies on the development of the spinal cord, the anatomically simplest part of the CNS, have generated most of our current knowledge on the signaling events and the genetic networks that orchestrate the DV patterning of the neural plate. In this review, we discuss the recent advances in our understanding of these events and highlight unresolved questions. We focused our attention on the activity and the integration of the three main instructive cues: Sonic hedgehog, the Wnts and the Bone Morphogenetic Proteins, giving particular attention to the less well understood dorsal signaling events.
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| http://dx.doi.org/10.1002/dneu.22015 | DOI Listing |
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